Health and Rehabilitation Sciences
516R Atwell Hall
453 W. 10th Ave.
Columbus, Ohio 43210
Primary Professional Areas of Interest
Research FocusIndividuals with neurodegenerative diseases such as Parkinson disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) experience declines in balance and gait that over time lead to falls and decreased quality of life. Our Mobility and Exercise in Neurodegenerative Disorders (MEND) lab is focused on research related to assessments and interventions to improve balance and gait and prevent falls in individuals with neurodegenerative diseases. The MEND Lab researchers created a HD Exercise Video with support from the OSU Huntington's Disease Center of Excellence and the OSUMC Service Board.
In the area of assessments, we have conducted studies to determine the best outcome measures to detect balance and gait impairments, predict fall risk, and measure changes in these areas over time in individuals with ALS, PD, HD, Dementia with Lewy bodies, and Alzheimer’s disease. Our lab has conducted studies to determine effective interventions to ameliorate balance and gait impairments and prevent falls in individuals with HD, PD, and multiple sclerosis. Beneficial effects of interventions such as the use of rollator walkers, playing the video game Dance Dance Revolution, treadmill walking, and administration of the anti-choreic medication tetrabenazine on balance and gait measures were demonstrated in these studies. Our restorative approach of using targeted interventions to improve or maintain balance and gait functions through intensive training or medication to induce neuroplastic changes rather than through compensation is innovative in the field.
Kloos, A., Fritz, N., Kostyk, S., Young, G., Kegelmeyer, D. (2014). Clinimetric properties of the Tinetti Mobility Test, Four Square Step Test, Activities-Specific Balance Confidence Scale, and spatiotemporal gait measures in individuals with Huntington's disease. Gait Posture, 40(4), 647-651.
Kloos, A., Fritz, N., Kostyk, S., Young, G., Kegelmeyer, D. (2013). Video game play (Dance Dance Revolution) as a potential exercise therapy for Huntington’s disease: a controlled clinical trial. Clin Rehabil, 27(11), 972-982.
Kloos, A., Fiumedora, N., Fritz, N., Kostyk, S., Kegelmeyer, D. (2015). Safety and feasibility of treadmill training in ambulatory individuals with Huntington's disease. J Neurol Phys Ther, 39, 73.
Kegelmeyer, D., Kloos, A., Fritz, N., et al. (2014). Comparison of gait and mobility measures in dementia with Lewy bodies, Parkinson's disease with dementia, Alzheimer's disease, and Parkinson's disease. Mov Disord, 29(10), E2.
- HTHRSC 5510: Pharmacology
- PT 8065S Service Learning in Physical Therapy
- PT 8998 Research Practicum
- PT 8250 Adult Neurologic Rehabilitation
- HTHRSC 7700S Service Learning in Merida, Mexico
- PT 8999 Thesis (Case Studies)
- PT 8013: Contemporary Issues
- PT 7250 Neurologic Basis of Rehabilitation
- PT 8650 Advanced Neurologic Rehabilitation
- 1980: BS, Physical Therapy, University of Wisconsin
- 1987: MS, Biology, Cleveland State University
- 2000: PhD, Biology, Cleveland State University