The National Clinical Trials Network (NCTN) Alliance for Clinical Trials in Oncology represents a merger of three former NCI-funded cancer cooperative groups including the American College of Surgeons Oncology Group (ACOSOG), the Cancer and Leukemia Group B (CALGB) and the North Central Cancer Treatment Group (NCCTG). Combined, these groups and their associated biorepositories represent an unequaled resource of expertise, institutional infrastructure and high quality, highly annotated patient biospecimens collected from several decades of cancer therapeutic trials. The scientific mission of the Alliance is to conduct high quality multidisciplinary cancer control, prevention and treatment trials to further our understanding of the biological basis of cancer and its treatment to affect change in clinical practice and, to provide the scientific and operational infrastructure for innovative clinical and translational research in the academic and community settings.

The Alliance Biorepository at The Ohio State University (ABOSU) serves as the largest biorepository serving the Alliance clinical trials. It is located at within Ohio State's Department of Pathology. The ABOSU receives, processes, stores and distributes formalin-fixed, paraffin-embedded (FFPE) blocks, core and slides, as well as frozen tissue, peripheral blood, plasma, serum and urine from institutions participating in Alliance clinical trials. ABOSU operations also include processing of biospecimens to isolate serum, plasma and DNA for storage, TMA construction and virtual microscopy for remote pathology review. The ABOSU currently has over 500,000 tissue and fluid biospecimens banked. It generally receives over 20,000 biospecimens per year and distributes between 5,000 and 10,000 per year.

The Digital Pathology Core (PC) is a supporting service of the Alliance Biorepository.

Alliance Biorepository at Ohio State

Alliance Biorepository at Ohio State

Proposals for specimen utilization

Proposals for specimen utilization

Additional Resources

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